Downtown Charleston Homes with Mother In Law Suites

Mother-in-Law Suites are not very common in the Historic Downtown Charleston, SC real estate market. Due to the size of the lots on the peninsula and the nature of their first use, mother in law suites in Downtown Charleston are a rare find.. Of course there are opportunities to purchase multi family properties and use the additional space as a mother in law suite if needed. When looking for a home with a mother in law suite in Historic Downtown Charleston, consider checking the zoning for the area, as it is important information to have for insurance purposes. These are all of the homes for sale with Mother-in-Law suites in the Historic Downtown Charleston, SC real estate market.


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49 Photos 66 America Street UNIT A&B Charleston, SC 29403

66 America Street UNIT A&B
Charleston, SC 29403
Eastside
Residential

MLS# 26005754 / Active
6 br, 4 ba, 2800 Sqft

This beautifully renovated historic duplex features two units, each with 3 bedrooms and a flex space that has been used as a 4th bedroom. Located i... 

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$1,199,000
Provided courtesy of Keller Williams Realty Charleston West Ashley
75 Photos 163 Coming Street Charleston, SC 29403

163 Coming Street
Charleston, SC 29403
Radcliffeborough
Residential

MLS# 26005685 / Active
10 br, 6 ba, 4129 Sqft

163 & 163.5 Coming Street present a rare multi-unit investment opportunity in the heart of downtown Charleston. Ideally positioned just three block... 

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$2,295,000
Reduced -$100,000
Provided courtesy of The Exchange Company, LLC
22 Photos 52 S Battery UNIT E Charleston, SC 29401

52 S Battery UNIT E
Charleston, SC 29401
South Of Broad
Residential

MLS# 26005438 / Active
2 br, 2 ba, 974 Sqft

Set within a distinguished Colonial Revival home on prestigious South Battery, this exquisite second-floor residence offers the rare opportunity to... 

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$870,000
Reduced -$25,000
Provided courtesy of Constant Properties
38 Photos 214 Calhoun Street UNIT #7 Charleston, SC 29401

214 Calhoun Street UNIT #7
Charleston, SC 29401
Fredrick Shaffer House
Residential

MLS# 26005109 / Active
2 br, 2 ba, 1017 Sqft

Welcome to this stunning, fully furnished, turn-key, 2 bed/2 bathroom penthouse in the heart of downtown Charleston. This gorgeous condo located in... 

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$985,000
Reduced -$5,000
Provided courtesy of Carolina One Real Estate
75 Photos
Open House: Tomorrow 10:00am - 7:00pm
54 Church Street Charleston, SC 29401

54 Church Street
Charleston, SC 29401
South Of Broad
Residential

MLS# 26004931 / Active
4 br, 5 ba, 2 Half Bath, 4852 Sqft

Located within one of the most exclusive enclaves of downtown Charleston--introduced by the historic charm of Stoll's Alley, the iconic pedestrian ... 

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$8,699,000
Reduced -$299,500
Provided courtesy of EXP Realty LLC
75 Photos 40 Montagu Street Charleston, SC 29401

40 Montagu Street
Charleston, SC 29401
Harleston Village
Residential

MLS# 26004897 / Active
4 br, 4 ba, 1 Half Bath, 4500 Sqft

Circa 1891, the Bernard Wohlers House is a rare architectural jewel nestled in the heart of Charleston's coveted Harleston Village. Perfectly blend... 

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$5,295,000
Reduced -$455,000
Provided courtesy of The Cassina Group
7 Photos 266 Ashley Avenue Charleston, SC 29403

266 Ashley Avenue
Charleston, SC 29403
City Of Charleston
Residential

MLS# 26004882 / Active
2 br, 2 ba, 1337 Sqft

Darling Pied-a-terre mere steps from all downtown living has to offer. well renovated freedman-style dwelling melds 19th century charm with modern ... 

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$750,000
Reduced -$20,000
Provided courtesy of Carolina One Real Estate
38 Photos 829 Rutledge Avenue Charleston, SC 29401

829 Rutledge Avenue
Charleston, SC 29401
Wagener Terrace
Residential

MLS# 26004655 / Active
4 br, 4 ba, 1 Half Bath, 1988 Sqft

This grand 1930's Craftsman on Rutledge Avenue has been completely restored to last a lifetime. Every possible attention to detail has been put int... 

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$1,345,000
Reduced -$50,000
Provided courtesy of Carolina One Real Estate
61 Photos 78 Vanderhorst Street Charleston, SC 29403

78 Vanderhorst Street
Charleston, SC 29403
Radcliffeborough
Residential

MLS# 26004624 / Active
3 br, 2 ba, 1 Half Bath, 1914 Sqft

78 Vanderhorst is a stunning 3-bedroom Charleston single built in the 1890s. It was raised 13.9 feet by Luxury Simplified Construction in 2020 and ... 

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$1,799,000
Reduced -$100,000
Provided courtesy of Realty One Group - Lowcountry
43 Photos 5016 Old Bridgeview Drive UNIT #5016 Charleston, SC 29403

5016 Old Bridgeview Drive UNIT #5016
Charleston, SC 29403
The Bristol
Residential

MLS# 26004439 / Active
2 br, 2 ba, 1626 Sqft

This gorgeous luxury condo located on the top floor of the Bristol, provides panoramic views of the Ashley River and the Bristol Marina. The privat... 

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$955,000
Reduced -$14,900
Provided courtesy of Land South of Charleston, LLC
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Broker Reciprocity The data relating to real estate for sale on this web site comes in part from the Broker ReciprocitySM Program of the Charleston Trident Multiple Listing Service. Real estate listings held by brokerage firms other than EXP Realty LLC are marked with the Broker ReciprocitySM logo or the Broker ReciprocitySM thumbnail logo (a little black house) and detailed information about them includes the name of the listing brokers. Last updated on 06-12-2026 3:04 PM EST . The broker providing these data believes them to be correct, but advises interested parties to confirm them before relying on them in a purchase decision. Copyright 2026 Charleston Trident Multiple Listing Service, Inc. All rights reserved.
Commercial Sale/Lease: Copyright 2026 South Carolina commercial MLS, Inc. All rights reserved. Last updated on 06-12-2026 3:04 PM EST est.

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